A Step Closer to Developing “Smart” Stem Cells – Cells With Regenerative Abilities – Made From Human Fat (Feb 2, 2021)
Researchers were able to generate induced multipotent stem cells from human fat cells. The cells were reprogrammed to act as stem cells and were then tested in mice. The study showed their effectiveness in adapting to their surroundings in order to repair a range of damaged tissues. In order to create the stem cells the scientists harvested fat and exposed it to a compound mixture that caused them to lose their original identity. This process also erased any “silencing marks,” which are responsible for restricting cell identity. Once these human stem cells were injected into mice, they remained dormant. However, once a mouse sustained an injury, these cells were activated and homed to that site.
Enzyme Plays Key Role in Waking Brain Stem Cells from Dormant State (Feb 12, 2021)
The Histone lysine methyltransferase Pr-set7/SETD8 has been found to reactivate neural stem cells in fruit flies. This enzyme woke them up from their quiescent state, which enabled them to proliferate and generate new neurons. It is becoming increasingly clear that this has a parallel in humans, who when experiencing issues with this enzyme and its variants (like KMT5A), have been found to suffer from neurodevelopmental disorders. Further studies are being conducted as to whether or not upregulation and activation of this enzyme can treat any of these or their symptoms.
Bone marrow ‘map’ opens path to organoid-like blood stem cell production (Feb 10, 2021)
In a new study, doctors and researchers were able to generate an atlas of bone marrow in humans—how tiny blood vessels organize the bone marrow and regulate how blood gets produced. Their findings indicate that the organization of vasculature dictates how and when blood is produced in the body. This is the first experiment of its kind in which the team did not have to destroy cells to trace their stages of development, they developed novel confocal imaging methods to observe blood cells in bone marrow.
A recipe for regenerating bioengineered hair (Feb 10, 2021)
Researchers in Japan have developed a way to induce continuous cyclical regeneration of cultured hair follicles from hair follicle stem cells, a novel breakthrough in treating patterns of baldness and regrowing hair where previously that ability was lost. After testing 220 combinations of growth factors, the researches discovered that the NFFSE medium (a type of collaged combined with five factors) led to the highest rate of stem cell amplification in the shortest time period.
FDA Approves Drug to Reduce Bone Marrow Suppression Caused by Chemotherapy (Feb 12, 2021)
In one of the latest treatments approved by the FDA, Cosela (Trilaciclib), is given before chemotherapy to protect bone marrow function. This makes it the first type of treatment in its class to reduce bone-marrow suppression related to chemotherapy. It aims to do so by reactivating an enzyme that chemotherapy has been found to inhibit—cyclin-dependent kinase 4/6. This would make chemotherapy safer for patients with extensive-stage small cell lung cancer.
FDA Announces New Resource for Veterinarians and Pet Owners Interested in Clinical Field Studies of Animal Cells, Tissues, and Cell- and Tissue-Based Products (Feb 8, 2021)
The FDA has just put forth a listing of clinical field studies that are investigating animal cells, tissues, and cell- and tissue-based products (ACTPs) in veterinary patients. This allows for more access to veterinary regenerative therapies, one of the fastest growing fields in medicine, human or otherwise.