Optimizing glucose regulation includes several pathways. It starts with limiting the absorption in the gut and then release of insulin from the pancreas, the sensitivity of insulin receptors on cells and final specific glucose utilization pathways.


Regulation of any of these areas will lead to improvement of fasting glucose, Hb1Ac levels ( a marker for effective glucose regulation over the last 3 months), lowering of cholesterol levels and free fatty acids and more.


As part of your health optimization journey focused on losing weight, getting your BMI in range of 18.9 to 24.9 the right lifestyle strategies must be applied. In doing so you do reduce the risk of metabolic syndrome, hypertension, cardiovascular disease and even cancer amongst some of the conditions of unregulated glucose levels. Any of these conditions can be devastating and for the most part avoidable.


Success even with the right strategies of nutrition, fasting, exercise or even sleep might be challenging. In that event, you may not have all the information you need to understand what is actually happening in your body and therefore missing the very thing that can make the difference.


That is why I do tell my clients – we need to keep looking and of course that does require additional tests like with Viome or the DNA Company if you have not done those yet.


And of course – you can also minimize/eliminate the consumption of processed foods and refined sugars as a start!


In the meantime however, there are certain supplements that will come in handy but I do wish to emphasize, keep on figuring out what is really happening that can be modified by lifestyle choices.


Gymnema Sylvestre

Gymnema has been used for centuries in traditional Ayurvedic medicine.

Increase insulin secretion

Increase glucose utilization

Inhibits glucose absorption in the intestines

Shown to lower cholesterol and triglycerides

Consume ten minutes before a carbohydrate containing meal



Found naturally in certain plant and used in traditional Chinese medicine for various conditions.

Helps regulate blood sugar: lowers fasting glucose and Hb1Ac

Reduces absorption of sugar in the gut

Reduces cholesterol, LDL

Supports heart health

Improves liver function

Helpful with the metabolic syndrome

Used in the treatment of type 2 diabetes

Aids in weight management

Reduction of inflammation

Recommended dosing between 500mg to 1500 mg

Divided doses with meals


Bitter Melon (bitter gourd)

Taxonomically known as Momordica charantia – a tropical vine closely related to zucchini, pumpkin and cucumber.

Shown to regulate blood sugar levels

May have cancer-fighting properties

Decreases cholesterol levels

Helps with weight loss

Reduction in inflammation


Activates cellular machinery to regulate energy production

Kion has a great formulation for bitter melon: Shop Kion Lean (getkion.com)

Dosing varies but usually within thirty minutes of your highest carbohydrate meal.


Any of these supplements may help you with the regulation of your blood sugar. The most important part is to continue to monitor the effects with either lab work, a constant glucose monitor (CGM), with the assistance of a health care professional to guide you. Any supplement may also have side effects. I do always recommend, investigate for yourself if any of these supplements should be tried.






This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Dr. Rademaker and any associates do not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.






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