New Bioink brings 3D-printing of human organs closer to reality

Scientists in Sweden have developed a 3D printing material that uses scaffolding made from the patients own stem cells. The finished products are biocompatible and support new blood vessel growth into the transplant site. Immediate intended use of this technology is recreating blood vessels in the lungs that have been damaged by chronic disease. It is also a step towards being able to 3D print organs that can be successfully transplanted.

Martina M. De Santis, Hani N. Alsafadi, Sinem Tas, Deniz A. Bölükbas, Sujeethkumar Prithiviraj, Iran A. N. Da Silva, Margareta Mittendorfer, Chiharu Ota, John Stegmayr, Fatima Daoud, Melanie Königshoff, Karl Swärd, Jeffery A. Wood, Manlio Tassieri, Paul E. Bourgine, Sandra Lindstedt, Sofie Mohlin, Darcy E. Wagner. Extracellular‐Matrix‐Reinforced Bioinks for 3D Bioprinting Human TissueAdvanced Materials, 2020; 33 (3): 2005476 DOI: 10.1002/adma.202005476


Self-organizing human heart organoids in a dish

3D printing hearts has just come a small step closer to us. Researchers are now able to create “cardioids” from human pluripotent stem cells. These are sesame-seed-sized heart models that when put in the proper growth medium able to support their survival will self-organize into a hollow chamber. They do this without the need of scaffolds. This implies some sort of organizing proclivity and assembly rules for heart tissue are encoded genetically in stem cells (and probably all cells).


How to boost muscle regeneration and rebuild tissue

(Clues about molecular changes underlying muscle loss tied to aging)

In an effort to help solve muscular degeneration related to age and athletic injury, Musculo-skeletal precursor cells called myogenic progenitors were added along with Yamanaka factors (transcription factors controlling how DNA is copied for translation). They were able to slow the production of Wnt4, which activated satellite cells in a niche cell environment in muscles that allowed for differentiation and proliferation of stem cells. The ability to do this allows for reconstruction to reverse age degeneration or injury in humans, but needs to be tested in other models because this experiment was carried out in mice.


Limit on lab-grown human embryos dropped by stem-cell body

New guidelines from the International Society for Stem Cell Research have relaxed the 14-day rule for culturing human embryos, which has previously been a hot-button topic. This gives researchers studying human pathologies more leeway and time to study disease progressions beyond early embryonic-states.

Major pull-quote: “In the past decade, scientists have made increasingly sophisticated models of embryos from human stem cells, demonstrating one way to study human development while avoiding the controversial use of embryos from fertility clinics. Such embryo-like structures are too rudimentary to grow into a person, scientists say. But relaxing the 14-day limit would allow researchers to compare them fully with real embryos, and test them as feasible stand-ins for research, says Lovell-Badge.”


No comments yet. Why don’t you start the discussion?

Leave a Reply

Your email address will not be published. Required fields are marked *